Improving on Nature: James Travis' Work on Recombinant Human α1-Proteinase Inhibitor
نویسندگان
چکیده
منابع مشابه
Improving on Nature: James Travis' Work on Recombinant Human α1-Proteinase Inhibitor.
In 1985, when recombinant DNA technology was still in its infancy, James Travis at the University of Georgia and colleagues developed a nonoxidizable form of a protein critical for preventing emphysema. Emphysema is an obstructive lung disease caused by progressive destruction of the lung tissue. The researchers synthesized the natural and variant forms of the protein through a partnership with...
متن کاملExpression of human α1-proteinase inhibitor in Aspergillus niger
BACKGROUND Human alpha1-proteinase inhibitor (alpha1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, alpha1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd) product. However, the plasma source i...
متن کاملInhibition of neutrophil elastase by recombinant human proteinase inhibitor 9.
Proteinase inhibitor PI9 (PI9) is an intracellular 42-kDa member of the ovalbumin family of serpins that is found primarily in placenta, lung and lymphocytes. PI9 has been shown to be a fast-acting inhibitor of granzyme B in vitro, presumably through the utilization of Glu(340) as the P(1) inhibitory residue in its reactive site loop. In this report, we describe the inhibition of human neutroph...
متن کاملLung deposition of inhaled α1-proteinase inhibitor in CF and α1-antitrypsin deficiency
s Issue, April 2008) and Canadian Respiratory Journal (in press).
متن کاملin translation: translators on their work and what it means
کتاب در باب ترجمه، اثر استر آلن و سوزان برنوفسکی منتشر شده در ماه می 2013 توسط نشریه کلمبیا است. نویسندگان در این کتاب به بررسی 18 مترجم با در نظر گرفتن نقش آثاری که این مترجمان ترجمه کرده اند میپردازند. کتاب به دو بخش تقسیم میشود: " مترجم در جهان" و " کار مترجم" این دو بخش مقالات همیشگی ترجمه و موقعیت خاص ادبیات بیگانه در جهان وسیع امروزی را مورد خطاب قرار میدهد. در این کتاب مقالات متعددی از ن...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2017
ISSN: 0021-9258
DOI: 10.1074/jbc.o117.000001